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. 2021 Mar 20;46(3):376–386. doi: 10.1016/j.jgr.2021.03.005

Fig. 4.

Fig. 4

Antidepressant-like effects of Rb1 on synaptic functional changes in the hippocampal neurons of CUMS-exposed mice were attenuated by miR-134 overexpression. (A) Schematic diagram of LTP induction in the hippocampal Schaffer collateral–CA1 synaptic pathway. (B) The trend of fEPSP waveform and slope in the hippocampal CA1 region. (C) Recording of the fEPSP slope in the hippocampal CA1 region. Expression of synapse-associated proteins, including (D) Syn, (E) PSD-95, (F) GAP-43, (G) MAP-2, (H) NR2A, (I) NR2B, (J) GluR1, and (K) CaMKII. Data are presented as means ± SEM (n=3–5); ∗p < 0.05 and ∗∗p < 0.01 were considered statistically significant.