Table 3.
Summary of PET findings for studies focused on the infarcted myocardium.
| References | MI type | RGD-based tracer accumulation | RGD-based tracer changes according to time after the event | Correlation between RGD uptake and MI size | Other modalities used to determine the infarcted zones | Uptake pattern | Histological correlates | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Days after MI | Positive number | SUV values | Negative number | |||||||
| Sun et al. (16) | NR (one NSTEMI patient specified among the negative patients) | 3 days−2 years | 20/23 | SUVpeak 1.94 ± 0.48, SUV ratios 2.33 ± 1.04, with peak uptake 1 week after MI | 3 | No serial assessment. Peak uptake 1 week after MI. Plateau within 4–75 days after MI | Yes (r = 0.748, P = 0.001) | 99mTc-MIBI/cardiac 18F-FDG PET/CT | Patchy form, within the area of infarction or immediately around | NR |
| Jenkins et al. (19) | STEMI | 14 ± 7 days (n = 21) | 21 | TBRmean 1.34 ± 0.22 | 0 | Reduced intensity on second PET/CT scans | No (r = 0.03, P = 0.90) | Cardiac MRI | Within the area of infarction | Viable myocardium with widespread positive staining for αvβ3 integrin (exploratory analysis for two patients) |
| 76 ± 19 days (n = 17) | 17 | TBRmean 1.20 ± 0.21 | 0 | |||||||
| Makowski et al. (20) | 7 STEMI/5 NSTEMI | 31 ± 14 days | 5 | Lesion/blood 1.15 ± 0.06; lesion/liver 0.61 ± 0.18 | 7 | NR | Yes (moderate, r = 0.73, P = 0.016) | Cardiac MRI/[13N]NH3 PET | Within the area of infarction or immediately around | NR |
NR, not reported; MI, myocardial infarction; STEMI, ST-elevation myocardial infarction; NSTEMI, Non-ST-elevation myocardial infarction.
r = Pearson correlation analysis.