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. 2022 Apr 1;17(11):2351–2354. doi: 10.4103/1673-5374.335833

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Copyright: © Neural Regeneration Research

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Comparison between healthy and pathological hippocampal neurogenesis following traumatic brain injury.

Overview of hippocampal neurogenesis in the dentate gyrus of healthy (A) versus injured (B) tissue. Pathology is associated with increased proliferation that may deplete the regenerative pool, aberrant circuit integration (linked to epileptogenesis) and abnormal progenitor migration as well as altered morphology. Some pathological features of neurogenesis could be potentially restored (C) through exogenous stem cell transplantation (mesenchymal stem/stromal cells or neural stem cells), metformin administration or the use of neurotrophic factors.