Table 1.

Studies of receptors involved in Aβ transportation across the BBB

Authors	Experiment models /measures	Conclusion
Li et al., 2001	LRP-null Chinese hamster ovary cells	Differential function of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
Deane et al., 2003	Systemic Aβ infusion and studies in genetically manipulated mice	Aβ interaction with receptor for RAGE-bearing cells in the vessel wall resulted in transport of Aβ across the BBB.
Ober et al., 2004	Using single-molecule fluorescence microscopy to analyze exocytic processes in FcRn-GFP-transfected human endothelial cells	IgG may be bound to FcRn for several seconds after exocytosis.
Deane et al., 2008	Male mice on a C57BL/6 background	ApoE isoforms differentially regulated Aβ clearance from the brain.
Storck et al., 2016	Tamoxifen-inducible deletion of Lrp1 specifically within brain endothelial cells [Slco1c1-CreER(T2) Lrp1(fl/fl) mice]	Brain endothelial-specific Lrp1 deletion reduces plasma Aβ levels and elevates soluble brain Aβ.
Fang et al., 2018	mAPP mice with genetic deletion of RAGE (mAPP/RO)	RAGE-dependent signaling pathway regulated β- and γ-secretase cleavage of APP to generate Aβ.
Wang et al., 2018	db/db mice	Targeted inhibition of RAGE reduced amyloid-β influx across the BBB and improved cognitive deficits in db/db mice.
Kariolis et al., 2020	Human transferrin receptor-engineered mice and cynomolgus monkeys	Fc fragment-mediated transcytosis for central nervous system delivery of biotherapeutics was performed by binding endothelial cell target.

Aβ: Amyloid-beta; ApoE: apolipoprotein E; BBB: blood-brain barrier; LRP1: low density lipoprotein receptor (LDLR)-related protein 1; RAGE: advanced glycation end products.