Table 3.

A summary of future perspectives of new research strategies for amyloid-beta clearance in Alzheimer’s disease

No.	Future perspectives
1	The transporting process of receptors or transporters on endothelial cells, especially the intracellular process, is worthy of further study.
2	Using space transcriptome and other techniques to find more receptors, transporters and some genes involved in amyloid-beta clearance on vascular endothelial cells.
3	The blood-brain barrier should be studied as an entirety, not limited to endothelial cells.
4	Further researches on the blood-cerebrospinal fluid barrier and lymphoid-related pathway mediating amyloid-beta clearance from the brain into the periphery.
5	Studying the changes of potential levels and functions of receptors and ABC transporters of brain capillary endothelial cells in specific stages of Alzheimer’s disease in human postmortem and antemortem cohorts.
6	The study of early reliable biological markers neuroimaging for different types of vascular cells.