Figure 3.

Effect of UC-MSCs on the pathological changes in the brain tissue of neonatal rats with maternal immune activation-associated neonatal brain injury.

The widened pericapillary space and cerebral edema (red arrow) was observed in the cortex, CA1, CA3, and DG areas (Nissl staining, original magnification 200×, scale bars: 100 μm; original magnification in the enlarge parts 400×, scale bars: 50 μm). After intranasal hUC-MSCs administration, the neuronal structure was relatively clear. Stromal edema was reduced (green arrow). The number of neurons in the cerebral cortex of young rats in the LPS group was less than that in the control group, and the structure was loose. DG: Dentate Gyrus; LPS: lipopolysaccharides; PBS: phosphate-buffered saline; UC-MSCs: umbilical cord-derived mesenchymal stem cells.