Table 2:
Odds ratio of cancer by anatomic site of Medicare patients with Fuchs endothelial corneal dystrophy (FECD) versus those without FECD.
| Cancer type | Number diagnosed in cases with FECD diagnosis (N = 15,534) |
Number diagnosed in cases without FECD diagnosis (N = 1,447,206) |
Odds ratio* (95% confidence interval) |
P-value |
|---|---|---|---|---|
| Brain | 26 (0.2%) | 3,104 (0.2%) | 0.76 (0.52–1.13) | 0.18 |
| Breast | 784 (5.0%) | 47,142 (3.3%) | 1.32 (1.22–1.43) | <0.001 |
| Choroidal melanoma | 7 (0.0%) | 477 (0.0%) | 1.29 (0.70–2.72) | 0.51 |
| Colon | 181 (1.2%) | 17,210 (1.2%) | 0.92 (0.79–1.07) | 0.30 |
| Cutaneous basal cell | 1,871 (12.0%) | 126,716 (8.8%) | 1.42 (1.35–1.49) | <0.001 |
| Cutaneous melanoma | 166 (1.1%) | 12,917 (0.9%) | 1.20 (1.03–1.40) | 0.02 |
| Cutaneous squamous cell | 1,636 (10.5%) | 106,451 (7.4%) | 1.45 (1.38–1.53) | <0.001 |
| Kidney | 87 (0.6%) | 8,893 (0.6%) | 0.93 (0.75–1.15) | 0.50 |
| Leukemia | 179 (1.2%) | 14,547 (1.0%) | 1.11 (0.96–1.29) | 0.17 |
| Lung | 247 (1.6%) | 26,297 (1.8%) | 0.81 (0.71–0.93) | 0.003 |
| Lymphoma | 159 (1.0%) | 12,235 (0.8%) | 1.17 (1.00–1.37) | 0.06 |
| Malignant carcinoid of colon | 11 (0.1%) | 634 (0.0%) | 1.61 (0.89–2.93) | 0.12 |
| Ovarian (Females only) |
83 (0.8%) | 4,220 (0.5%) | 1.84 (1.48–2.30) | <0.001 |
| Prostate (Males only) |
635 (12.7%) | 62,898(10.3%) | 0.88 (0.81–0.96) | 0.002 |
| Testicular (Males only) |
2 (0.0%) | 332 (0.1%) | 0.70 (0.18–2.83) | 0.62 |
| Thyroid | 68 (0.4%) | 4,523 (0.3%) | 1.32 (1.04–1.68) | 0.02 |
| Uterine (Females only) |
68 (0.6%) | 5,299 (0.6%) | 1.01 (0.79–1.28) | 0.96 |
N = Number of patients at risk.
*
Odds ratios adjusted for age, race, sex (for non sex-specific malignancies), tobacco use, and Charlson comorbidity index.