Table 3.
Gene name | cBioPortal (585 patients) | Piccioni D.E.(419 patients) | TCGA/Pancancer (180 patients) | Our results for 25 GBM samples | |
---|---|---|---|---|---|
Tumour | cfDNA | ||||
TP53 | 31.50% | 58.70% | 28.0% | 30.0% | 32.0% |
IDH1 | 6.30% | 2.00% | 10.0% | 8.0% | 8.0% |
PTEN | 33.50% | 0.80% | 22.0% | 33.0% | 30.0% |
EGFR | 23.70% | 20.00% | 14.0% | 20.0% | 19.0% |
H3F3A | 0.80% | ― | 13.0% | 2.0% | 1.0% |
PIK3CA | 9.60% | 5.00% | 7.0% | 9.0% | 7.8% |
ATRX | 9.30% | — | 9.0% | 9.0% | 10.0% |
NF1 | 11.60% | 22.90% | 9.0% | 11.0% | 13.0% |
BRAF | 2.00% | 7.00% | 5.0% | 3.0% | 2.8% |
RB1 | 9.60% | 0.90% | 7.0% | 10.0% | 9.7% |
TERT | 1.30% | 2.80% | 4.0% | 4.5% | 5.0% |
PIK3R1 | 9.80% | — | 6.0% | 7.8% | 7.0% |
CHEK2 | 0.70% | — | 8.0% | 3.0% | 2.1% |
PDGFRA | 4.00% | 12.90% | 5.0% | 5.0% | 5.1% |
LRP1B | 3.30% | — | 5.0% | 4.0% | 4.3% |
SETD2 | 2.80% | — | 3.0% | 3.5% | 3.1% |
STAG2 | 4.50% | — | 3.0% | 5.0% | 5.2% |
HIF1A | 0.50% | — | 3.0% | 2.2% | 3.1% |
IRS4 | 1.00% | — | 4.0% | 4.0% | 3.6% |
KMT2C | 4.80% | — | 3.0% | 3.0% | 3.4% |
MET | 1.80% | 19.00% | 2.0% | 2.0% | 3.1% |
APC | 2.00% | 14.00% | 1.9% | 2.5% | 3.0% |
AR | — | 10.10% | 1.1% | 1.5% | 2.3% |
ERBB2 | 1.30% | 10.10% | 0.6% | 1.3% | 1.5% |
FGFR2 | 1.00% | 10.10% | 0.5% | 1.2% | 1.3% |
NOTCH1 | 0.50% | 8.90% | 1.5% | 1.5% | 2.0% |
KIT | 1.50% | 8.00% | 1.3% | 1.5% | 1.7% |
NRAS | 1.00% | 7.00% | 1.1% | 1.5% | 1.2% |
RAF1 | 0.80% | 7.00% | 0.4% | 1.2% | 0.8% |
CONE1 | — | 6.10% | — | — | — |
JAK2 | 1.30% | 6.10% | 1.1% | 2.1% | 1.9% |
ATM | 1.80% | 5.00% | 2.1% | 3.1% | 2.8% |
ALK | 0.80% | 4.00% | 1.3% | 1.3% | 3.05% |
BRCA1 | 1.50% | 3.90% | 2.0% | 3.7% | 3.5% |
BRCA2 | 1.50% | 3.90% | 1.7% | 3.8% | 3.7% |
MAP2K2 | 0.50% | 2.80% | 0.1% | 1.5% | 1.65% |
CCND2 | 0.50% | 2.00% | 0.8% | 0.8% | 0.9% |
CDK6 | 0.30% | 2.00% | 0.7% | 0.7% | 0.3% |
GATA3 | 0.50% | 1.90% | 0.5% | 0.9% | 0.76% |
GNAS | 0.80% | 1.90% | 0.6% | 1.2% | 1.3% |
HRAS | — | 1.90% | 0.5% | 0.7% | 1.1% |
JAK3 | 1.30% | 1.90% | 1.0% | 2.1% | 1.9% |
KRAS | 0.50% | 2.00% | 0.8% | 0.9% | 0.8% |
SMAD4 | 0.30% | 1.90% | 0.9% | 1.0% | 0.96% |
SMO | 0.50% | 1.90% | 0.7% | 1.4% | 1.43% |
STK11 | — | 1.90% | 0.8% | 1.2% | 1.3% |
TSC1 | 1.00% | 1.90% | 1.5% | 1.9% | 1.8% |
AKT1 | 0.50% | 0.90% | 0.2% | 0.9% | 1.2% |
ARAF | 0.80% | 0.90% | 0.2% | 0.8% | 1.2% |
CCND1 | — | 1.10% | 0.5% | 1.1% | 0.8% |
FBXW7 | 0.80% | 0.90% | 1.1% | 1.1% | 0.8% |
FGFR1 | 1.00% | 1.10% | 1.1% | 1.0% | 1.1% |
MAPK3 | 0.80% | 0.90% | 0.2% | 0.8% | 0.78% |
MLH1 | 0.30% | 0.90% | 0.9% | 0.9% | 1.2% |
NTRK1 | 0.80% | 0.90% | 0.6% | 0.8% | 1.1% |
NTRK3 | 1.30% | 0.90% | 1.3% | 1.3% | 0.9% |
RIT1 | 0.30% | 0.90% | 0.2% | 0.53% | 0.5% |
ROS1 | 2.50% | 0.90% | 2.2% | 2.5% | 2.1% |