Table 1.
Patient data. For continuous variables median (IQR, range) is given, for categorical variables number (%) is given. LOD, limit of detection.
| Clinical characteristics | Value |
|---|---|
| Age | 5 (3–13, 1–44) years |
| Gender | 93/105 (47/53%) male/female |
| WBC | 9 (4–28, 0.7–388) x 109·L−1 |
| High hyperdiploid | 64 (32%) |
| Hypodiploid | 6 (3%) |
| t(12;21) | 35 (18%) |
| t(1;19) | 5 (3%) |
| iAMP21 | 7 (4%) |
| dic(9;20) | 2 (1%) |
| KMT2A‐rearranged | 4 (2%) |
| No cytogenetic aberration | 77 (39%) |
| EOI risk stratification: SR/IR/HR/HR+HSCT | 84/89/13/12 (42/45/7/6%) |
| EOI FCM‐MRD | 1.3 × 10−3 (7.4 × 10−5–4.7 × 10−3, < LOD‐6.7 × 10−1) |
| Follow‐up time | 73 (57–92, 2–117) months |
| Relapse | 18 (9.0%, CI 4.9–13.0% a ) |
| Nonrelapse mortality | 9 (4.6%, CI 1.7–7.5% a ) |
a
5‐year cumulative incidence of relapse/cumulative incidence of nonrelapse mortality.