Table 1.
Results of Mendelian randomization (MR) analysis of the associations between workplace environments and plasma protein levels using three MR methods.
| Exposures | SNPs | IVW | MR Egger | Weighted median | |||
|---|---|---|---|---|---|---|---|
| Outcomes | β (se) | pval | β (se) | pval | β (se) | pval | |
| Noisy | |||||||
| IGFBP1 | 18 | −0.309 (0.102) | 0.002 | −0.73 (0.286) | 0.021 | −0.429 (0.139) | 0.002 |
| SCG3 | 18 | −0.285 (0.128) | 0.026 | −0.92 (0.328) | 0.013 | −0.307 (0.156) | 0.048 |
| ST3GAL2 | 18 | 0.229 (0.108) | 0.034 | 0.806 (0.286) | 0.012 | 0.338 (0.144) | 0.019 |
| ST3GAL6 | 18 | −0.329 (0.102) | 0.001 | −0.805 (0.286) | 0.012 | −0.328 (0.142) | 0.021 |
| UNC5D | 18 | −0.316 (0.125) | 0.011 | −0.751 (0.341) | 0.043 | −0.342 (0.147) | 0.020 |
| Hot | |||||||
| COL1A1 | 13 | −0.277 (0.095) | 0.003 | −0.532 (0.21) | 0.028 | −0.364 (0.132) | 0.006 |
| Dusty | |||||||
| GJA8 | 15 | 0.198 (0.089) | 0.026 | 0.527 (0.22) | 0.032 | 0.228 (0.114) | 0.045 |
| Chemical fumes | |||||||
| ACYP2 | 20 | 0.178 (0.065) | 0.006 | 0.45 (0.127) | 0.002 | 0.186 (0.085) | 0.029 |
| CRKL | 20 | 0.134 (0.061) | 0.028 | 0.272 (0.127) | 0.046 | 0.186 (0.08) | 0.019 |
| CSNK1G2 | 20 | 0.138 (0.061) | 0.023 | 0.284 (0.127) | 0.038 | 0.179 (0.082) | 0.028 |
| CXCL1 | 20 | 0.148 (0.073) | 0.042 | 0.43 (0.137) | 0.006 | 0.171 (0.082) | 0.038 |
| EFNA3 | 20 | −0.159 (0.066) | 0.017 | −0.311 (0.136) | 0.035 | −0.165 (0.081) | 0.042 |
| EIF1AD | 20 | 0.179 (0.07) | 0.010 | 0.363 (0.141) | 0.019 | 0.187 (0.085) | 0.028 |
| FAM107B | 20 | 0.217 (0.061) | 0.000 | 0.428 (0.127) | 0.003 | 0.201 (0.084) | 0.017 |
| FYN | 20 | 0.192 (0.062) | 0.002 | 0.505 (0.127) | 0.001 | 0.168 (0.085) | 0.048 |
| GRB2 | 20 | 0.151 (0.061) | 0.013 | 0.284 (0.127) | 0.038 | 0.189 (0.086) | 0.028 |
| HS3ST3A1 | 20 | 0.166 (0.061) | 0.006 | 0.275 (0.127) | 0.043 | 0.178 (0.086) | 0.039 |
| PAPSS1 | 20 | 0.121 (0.061) | 0.046 | 0.325 (0.127) | 0.019 | 0.169 (0.084) | 0.043 |
| RBM39 | 20 | 0.209 (0.061) | 0.001 | 0.407 (0.127) | 0.005 | 0.224 (0.081) | 0.006 |
| RPSA | 20 | 0.18 (0.061) | 0.003 | 0.294 (0.127) | 0.032 | 0.18 (0.083) | 0.031 |
| STAT3 | 20 | 0.168 (0.061) | 0.006 | 0.311 (0.127) | 0.024 | 0.161 (0.082) | 0.049 |
| TFF1 | 20 | −0.148 (0.068) | 0.029 | −0.468 (0.127) | 0.002 | −0.222 (0.085) | 0.009 |
| Passive smoking | |||||||
| ADCYAP1 | 18 | −0.275 (0.096) | 0.004 | −0.534 (0.23) | 0.034 | −0.284 (0.132) | 0.031 |
| CA10 | 18 | 0.417 (0.106) | 0.000 | 0.604 (0.255) | 0.031 | 0.546 (0.142) | 0.000 |
| NRSN1 | 18 | −0.26 (0.112) | 0.020 | −0.56 (0.262) | 0.048 | −0.299 (0.132) | 0.023 |
| TMEM132A | 18 | 0.252 (0.096) | 0.009 | 0.552 (0.229) | 0.029 | 0.291 (0.133) | 0.029 |
| Diesel exhaust | |||||||
| LILRB2 | 22 | −0.145 (0.044) | 0.001 | −0.237 (0.091) | 0.017 | −0.165 (0.06) | 0.006 |
| TENM4 | 22 | 0.143 (0.044) | 0.001 | 0.221 (0.091) | 0.025 | 0.159 (0.058) | 0.006 |