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. 2022 May 18;154(6):e202113074. doi: 10.1085/jgp.202113074

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© 2022 Jensen et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Depletion of PtdIns(4,5)P₂ in response to a muscarinic agonist (Oxo-M) in cell lines. The diamonds show loss of FRET when FRET pairs PH_PLCδ1-CFP and PH_PLCδ1-YFP translocate from being bound near each other at the plasma membrane to being free in the cytoplasm, and the triangles show appearance of PH_PLCδ1-YFP in the cytoplasm from confocal images (transfected tsA201 cells). Circles are PtdInsP₂ from mass spectrometry (mass spec, in CHO-M cells stably expressing M₁ receptors), and colored lines are amplitudes of KCNQ2/3 current (tsA201 cells; Jensen et al., 2009; from Traynor-Kaplan et al., 2017).