Table 2.

Decomposition energies per residue in kcal/mol for the main mutation positions of RBD WT, Alpha, Delta and Omicron.

SARS-CoV-2		Alpha		Delta		Omicron
G339	0.7		0.8		0.8	G339D	68.4
S371	0.8		0.4		1.1	S371L	0.8
S373	1.0		0.6		0.9	S373P	0.6
S375	− 0.3		− 0.3		− 0.1	S375F	− 0.4
K417	− 121.2		− 131.5		− 112.4	K417N	− 2.3
N440	− 0.4		− 0.3		− 0.2	N440K	− 98.6
G446	0.3		− 0.2		− 0.2	G446S	1.2
L452	− 0.7		− 0.6	L452R	− 90.5	L452	− 1.4
S477	− 1.1		− 1.7		− 1.4	S477N	− 0.6
T478	0.7		− 2.4	T478K	− 82.6	T478K	− 85.8
E484	88.2		94.4		93.8	E484A	0.1
Q493	− 8.7		− 11.6		− 8.8	Q493R	− 163.7
G496	− 3.6		− 3.1		− 4.9	G496S	− 6.3
Q498	− 6.7		− 2.1		− 7.4	Q498R	− 161.0
N501	− 8.6	N501Y	− 8.1		− 10.1	N501Y	− 2.2
Y505	− 7.4		− 5.5		− 8.0	Y505H	− 1.4