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. 2022 May 17;80:104058. doi: 10.1016/j.ebiom.2022.104058

Figure 2.

Fig 2

Distributional bias of tumor somatic mutations in non-HVS and HVS of mtDNA control region. (a) Distribution of somatic mutations in different regions of mtCTR in total mutation dataset. Mutation hotspots (mutation number was at least 10 times higher than the average mutation number of mtCTR, that is no less than 12) were colored in red. HVS, hypervariable segment. (b) Distribution of somatic mutations in different regions of mtCTR across 20 tumor types. Tissues were lined from top to bottom according to the total mutation number of mtCTR. (c and d) Comparison of mutation density or average mutation sites between HVS and non-HVS of mtDNA control region in tumor types. (e and f) Spearman rank correlation between the general MD of tumor and the MD of HVS or the MD of non-HVS. P values were calculated from Mann Whitney U test.