Figure 5.

Mutational pattern of mtDNA control region was associated with tumor mitochondrial dysfunction. (a) Comparison of mutation density between non-HVS and HVS in four tumor types. P values were from Fisher's exact test. (b) Ratio of MD_non-HVS/HVS among four tumor types. (c-f) Comparison of mtDNA copy number among samples without mutations in mtDNA control region (no mtCTR muts), samples with HVS mutations (HVS muts) and samples with non-HVS mutations (non-HVS muts) in CRC, RCC, HCC and OV. P values were from Mann Whitney U test. (g) Gene expression change of 15 mtDNA genes between tumor samples with HVS mutations and non-HVS mutations in CRC, RCC and HCC. The bubble colors from red to blue correspond to Log₂ fold change of gene expression level from high to low in non-HVS group compared to HVS group. *P<0.05, **P<0.01.