Table 1. Outcomes of Patients With MIS-C in 12 Israeli Hospitals During the Alpha, Delta, and Omicron Waves.
| Outcome | Alpha wavea (n = 59) | Delta wavea (n = 79) | Omicron wavea (n = 33) |
|---|---|---|---|
| Cardiac variables | |||
| NT-proBNP level, median (IQR), pg/mL | 2961 (931-15 900) | 2275 (799- 4919) | 1068 (435-5933) |
| Troponin level, median (IQR), ng/L | 10 (5-113) | 23 (13-57) | 55 (25-157) |
| Reduced left ventricular function, No. (%)b | 5 (8.5) | 6 (7.6) | 1 (3.0) |
| Length of stay and admission to ICU | |||
| Hospital length of stay, median (IQR), d | 6 (5-8) | 6 (5-8.5) | 4 (3-6) |
| ICU length of stay, median (IQR), d | 3 (2-6) | 4 (2-6) | 4 (2-6) |
| ICU admission, No. (%) | 34 (57.6) | 39 (49.4) | 7 (21.2) |
| ICU treatment, No. (%) | |||
| Vasopressors | 13 (22.0) | 14 (17.7) | 2 (6.0) |
| Mechanical ventilation | 5 (8.5) | 7 (8.9) | 0 |
| Extracorporeal membrane oxygenation | 0 | 2 (2.5%) | 0 |
Abbreviations: ICU, intensive care unit; NT-proBNP, N-terminal fragment of the prohormone brain natriuretic peptide.
a
Each wave was a 16-week period: Alpha, December 20, 2020, to April 10, 2021; Delta, July 18, 2021, to November 13, 2021; and Omicron, November 21, 2021, to March 12, 2022.
b
All patients underwent echocardiography within 24 hours of admission. The definition of reduced function was an ejection fraction less than 40%.