. 2022 May 19;327(24):2452–2454. doi: 10.1001/jama.2022.8025

Table 2. Nationwide Data on the Incidence of MIS-C During the Alpha, Delta, and Omicron Waves in Israel .

Pandemic wave data^a	Alpha	Delta	Omicron	Total
MIS-C cases, No. (%)^b	103 (40.5)	115 (45.3)	36 (14.2)	254
SARS-CoV-2 infections in persons younger than 18 y, No.^c	188 800	233 585	946 779	1 369 164
MIS-C incidence rate^d	54.5	49.2	3.8
MIS-C incidence rate ratio (95% CI)^e	14.34 (9.81-20.96)	12.94 (8.90-18.81)	1 [Reference]

^{^a}

Each wave was a 16-week period: Alpha, December 20, 2020, to April 10, 2021; Delta, July 18, 2021, to November 13, 2021; and Omicron, November 21, 2021, to March 12, 2022.

^{^b}

Cases of multisystem inflammatory syndrome in children (MIS-C) were limited to patients aged 0 to 18 years.

^{^c}

According to the Israel Ministry of Health SARS-CoV-2 data set.

^{^d}

Incidence rates were calculated using number of cases as numerator, with number of SARS-CoV-2 pediatric infections as denominator, per 100 000.

^{^e}

Incidence rate ratios use the rate of MIS-C cases in the Omicron wave as a referent group, with 95% CIs.