Table 2.
Patient | AD (n) | AD Events | WHO Classificationa | TET Diagnosis to First AD (mo)b | AD Treatments |
---|---|---|---|---|---|
1 | 6 | CASPR2 encephalitis; Good syndrome; enteropathy; minimal change disease; MG; Sweet syndrome | Type B | N/A | Azathioprine, cyclophosphamide, cyclosporine, daratumumab, everolimus, IVIG, plasmapheresis, rituximab, steroids, tacrolimus |
2 | 1 | MG | Type B | N/A | IVIG, mycophenolate, pyridostigmine, steroids |
3 | 1 | MG | Type B | 84 | None |
4 | 2 | Good syndrome; MG | Type B | N/A | Azathioprine, pyridostigmine, plasmapheresis |
5 | 1 | Neuropathy | Type B | N/A | IVIG, steroids |
6 | 1 | MG | Type B | N/A | Pyridostigmine |
7 | 3 | Amegakaryocytic thrombocytopenia; arthritis; PRCA | Type B | 160 | Steroids |
8 | 1 | MG | Type AB | 1 | None |
9 | 1 | PRCA | Type AB | 39 | Steroids |
10 | 1 | PRCA | Thymoma, NOS | 172 | Steroids |
11 | 2 | Enteropathy, neutropenia | Thymoma, NOS | 47 | Everolimus, octreotide, steroids |
12 | 1 | PRCA | Thymoma, NOS | 168 | None |
13 | 3 | Dermatomyositis, pemphigus vulgaris, MG | Thymoma, NOS | N/A | Mycophenolate, pyridostigmine, steroids |
14 | 1 | PRCA | TC | 30 | Cyclosporine, IVIG, steroids |
15 | 1 | ITP | TC | 30 | Steroids |
16 | 2 | Arthritis; Good syndrome | Thymic neoplasm | 184 | IVIG, methotrexate, steroids |
AD, autoimmune disease; ITP, immune thrombocytopenic purpura; IVIG, intravenous immune globulin; MG, myasthenia gravis; N/A, not applicable; NOS, not otherwise specified; PRCA, pure red cell aplasia; TC, thymic carcinoma; TET, thymic epithelial tumor.
Thymoma listed as type A, type B, or type AB.
Cases where AD preceded TET diagnosis, including those with multiple ADs if at least one AD occurred before TET diagnosis, were designated as N/A.