Table 4. Uptake (SUV) of [⁶⁸Ga]Ga-NOTA-Insulin without and with the Insulin Receptor Inhibitor (+S961) in Different Brain Regions of Normal (B6SJL) and AD (APP/PS1) Mouse Models at 30 min Post Intravenous Administration Measured via Organ/Tissue Harvesting.

	SUV: mean ± SD				adj. P value
mouse brain regions	AD (n = 12)	AD (+S961) (n = 5)	normal (n = 13)	normal (+S961) (n = 3)	AD vs normal	AD (+S961) vs normal (+S961)	normal vs normal (+S961)	AD vs AD (+S961)
caudate nucleus	0.021 ± 0.007	0.018 ± 0.001	0.019 ± 0.007	0.017 ± 0.0055	0.403	0.888	0.955	0.613
cortex	0.023 ± 0.007	0.032 ± 0.001	0.014 ± 0.003	0.02 ± 0.0062	0.002	0.221	0.310	0.077
hippocampus	0.035 ± 0.014	0.068 ± 0.031	0.027 ± 0.010	0.021 ± 0.0016	0.220	0.045	0.115	0.147
thalamus	0.032 ± 0.007	0.045 ± 0.011	0.020 ± 0.005	0.028 ± 0.0093	0.002	0.240	0.341	0.240
brain stem	0.034 ± 0.008	0.049 ± 0.001	0.024 ± 0.008	0.029 ± 0.0038	0.019	0.032	0.215	0.019
cerebellum	0.040 ± 0.011	0.051 ± 0.001	0.025 ± 0.005	0.032 ± 0.013	0.002	0.290	0.538	0.139