Table 5. Uptake (SUV) of [⁶⁸Ga]Ga-NOTA-Insulin without and with the Insulin Receptor Inhibitor (+S961) in Normal (B6SJL) and AD (APP/PS1) Mouse Models at 30 min Post Intravenous Administration Measured via Organ/Tissue Harvesting.

	SUV: mean ± SD				adj. P value
organ/tissue	AD (n = 12)	AD (+S961) (n = 5)	normal (n = 13)	normal (+S961) (n = 3)	AD vs normal	AD (+S961) vs normal (+S961)	normal vs normal (+S961)	AD vs AD (+S961)
blood	0.658 ± 0.194	0.955 ± 0.331	0.447 ± 0.21	0.591 ± 0.038	0.051	0.173	0.076	0.221
heart	0.520 ± 0.122	0.635 ± 0.181	0.620 ± 0.142	0.486 ± 0.0197	0.290	0.295	0.087	0.373
lungs	1.115 ± 0.221	1.366 ± 0.361	0.830 ± 0.167	1.097 ± 0.214	0.016	0.373	0.225	0.315
liver	1.293 ± 0.395	2.217 ± 1.251	1.582 ± 0.294	1.070 ± 0.055	0.152	0.220	0.002	0.290
spleen	0.566 ± 0.185	1.021 ± 0.591	0.519 ± 0.094	0.545 ± 0.0211	0.701	0.220	0.484	0.220
pancreas	0.422 ± 0.103	0.489 ± 0.131	0.644 ± 0.202	0.323 ± 0.078	0.044	0.225	0.100	0.484
bone	0.305 ± 0.077	0.359 ± 0.061	0.242 ± 0.073	0.237 ± 0.027	0.087	0.048	0.863	0.249
gut	0.755 ± 0.177	0.510 ± 0.121	1.414 ± 0.316	0.422 ± 0.085	0.026	0.483	0.004	0.139
feces	0.098 ± 0.105	0.045 ± 0.031	0.830 ± 1.325	0.056 ± 0.030	0.290	0.660	0.267	0.483
adipose	0.153 ± 0.072	0.214 ± 0.121	0.251 ± 0.083	0.366 ± 0.086	0.064	0.215	0.195	0.473
stomach	0.258 ± 0.096	0.371 ± 0.141	0.447 ± 0.327	0.300 ± 0.086	0.215	0.574	0.484	0.240
skin	0.413 ± 0.117	0.570 ± 0.241	0.478 ± 0.095	0.582 ± 0.142	0.229	0.862	0.483	0.290
muscle	0.234 ± 0.073	0.210 ± 0.031	0.219 ± 0.038	0.195 ± 0.048	0.591	0.695	0.610	0.564
cecum	0.177 ± 0.055	0.277 ± 0.141	0.227 ± 0.070	0.175 ± 0.023	0.225	0.341	0.267	0.325
eyes	0.235 ± 0.111	0.295 ± 0.091	0.189 ± 0.058	0.241 ± 0.057	0.912	0.547	0.310	0.341
bladder	5.59 ± 7.969	4.297 ± 3.571	0.852 ± 0.335	6.550 ± 3.265	0.019	0.341	0.019	0.912
kidneys	33.348 ± ± 7.118	33.144 ± 8.551	27.010 ± 4.926	36.689 ± 7.604	0.088	0.613	0.240	0.955
urine	11.405 ± 10.548	20.892 ± 14.51	4.973 ± 6.119	14.900 ± 5.880	0.337	0.881	0.045	0.310