Jeyashree 2021.

Study characteristics
Patient Sampling	Purpose: diagnosis of SARS‐CoV‐2 infection (mild COVID‐19 disease); to describe the symptom profile of people who underwent testing for COVID‐19 Design: cross‐sectional cohort study, prospective data collection Recruitment: all consecutive adults who visited COVID‐19 testing centres in Chennai city in Southern India Sample size: n = 277 (58 cases) Inclusion criteria: all consenting adults aged 18‐80 years belonging to any gender, who visited COVID‐19 testing centres in Chennai city in Southern India Exclusion criteria: none specified
Patient characteristics and setting	Facility cases: positive RT‐PCR test for SARS‐CoV‐2 Facility controls: negative RT‐PCR test for SARS‐CoV‐2 Country: India Dates: not specified (2020) Symptoms and severity: not specified, mild to moderate severity Demographics: overall age: mean 40.7 years M%/F%: cases 51.7/48.3, controls 63.5/36.5 Exposure history: history of close contact with COVID‐19 patient: cases 9%, controls 5%
Index tests	Fever Headache Cough Runny nose Joint pain Muscle aches Sore throat Fatigue/malaise Loss of smell or taste Loss of smell Loss of appetite Chills Loss of taste Vomiting Altered conscious Bleeding DIarrhoea Conjunctivitis Wheezing Chest pain Skin rash Pain abdomen Shortness of breath
Target condition and reference standard(s)	TC: SARS‐CoV‐2 infection RS: RT‐PCR, nasopharyngeal swab
Flow and timing	Index tests were collected on same day of the specimen collection, and prior to the declaration of COVID‐19 test results
Comparative
Notes	Funding: supported by the Indian Council of Medical Research‐ National Institute of Epidemiology (ICMR‐NIE)
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
Did the study avoid inappropriate inclusions?	Yes
Could the selection of patients have introduced bias?		Low risk
Are there concerns that the included patients and setting do not match the review question?			Low concern
DOMAIN 2: Index Test (All tests)
Were the index test results interpreted without knowledge of the results of the reference standard?	Yes
If a threshold was used, was it pre‐specified?	Yes
Could the conduct or interpretation of the index test have introduced bias?		Low risk
Are there concerns that the index test, its conduct, or interpretation differ from the review question?			Low concern
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Could the reference standard, its conduct, or its interpretation have introduced bias?		Low risk
Are there concerns that the target condition as defined by the reference standard does not match the question?			Low concern
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
Could the patient flow have introduced bias?		Low risk