Table 3.
Multivariable results for Insurance Status: Pooled effects from two mixed-effects Cox models for long-term survival.
| Factor | Model 1: HR (95% CI), p-value | Model 2: HR (95% CI), p-value |
|---|---|---|
| Insurance (vs. Medicare/Medicaid) | Overall p=.335 | Overall p<.0001 |
| Private | 1.0 (.914,1.13), .792 | 0.68 (.620,.741), <.0001 |
| Uninsured | 1.2 (.751,1.81), .497 | 1.0 (.869,1.20), .813 |
| Race (vs. White, non-Hispanic) | Overall p=.549 | Overall p=.953 |
| White, Hispanic | 0.92 (.816,1.05), .207 | 0.89 (.786,1.00), .058 |
| Black, Non-Hispanic | 0.89 (.776,1.01), .077 | 1.1 (.971,1.20), .156 |
| Male gender (vs. female) | 1.2 (1.08,1.24), <.0001 | 1.1 (1.05,1.21), .001 |
| Age (HR multiplies for each year increase) | 1.1 (1.041,1.053), <.0001 | 1.02 (1.013,1.021), <.0001 |
| Year of diagnosis (HR multiplies per year) | 1.0 (.985,1.01), .739 | 1.0 (.984,1.01), .648 |
| Income (vs. <$38K/year) | Overall p<.0001 | Overall p=.0001 |
| $38,000-$47,999 | 0.93 (.835,1.05), .241 | 0.98 (.875,1.10), .730 |
| $48,000-$62,999 | 0.89 (.797,.999), .049 | 0.95 (.849,1.07), .384 |
| $63,000+ | 0.80 (.718,.902), .0002 | 0.86 (.767,.968), .012 |
| Miles from hospital (HR multiplies by per 10-mile increment) | 0.99 (.991,.998), .006 | 0.99 (.994,.999), .015 |
| Region (vs. West) | Overall p=.018 | Overall p=.001 |
| East | 1.1 (1.01,1.26), .033 | 1.2 (1.05,1.32), .006 |
| New England | 1.0 (.918,1.12), .764 | 1.1 (.950,1.17), .321 |
| Pacific/mountain | 1.1 (.968,1.24), .150 | 1.1 (.967,1.24), .150 |
| Population area (vs. Rural) | Overall p=.240 | Overall p=.749 |
| Metro | 1.1 (.845,1.40), .515 | 1.1 (.803,1.38), .705 |
| Metro adjacent | 1.2 (.899,1.53), .241 | 1.1 (.844,1.49), .425 |
| Not metro adjacent | 0.95 (.701,1.28), .730 | 1.1 (.766,1.44), .754 |
| Charlson/Deyo score (HR multiplies by per unit increase) | 1.2 (1.15,1.26), <.0001 | 1.1 (1.03,1.15), .002 |
| Disease site (vs. Other) | Overall p<.0001 | Overall p<.0001 |
| C250 | 1.6 (1.32,1.89), <.0001 | 1.3 (1.09,1.53), .003 |
| C251 | 1.3 (1.07,1.59), .008 | 1.1 (.896,1.31), .412 |
| C252 | 1.2 (.969,1.40), .105 | 1.0 (.853,1.20), .887 |
| C258 | 1.2 (.985,1.53), .067 | 1.1 (.859,1.29), .627 |
| C259 | 1.6 (1.32,1.92), <.0001 | 1.2 (1.00,1.43), .046 |
| Tumor type (vs. carcinoid) | Overall p<.0001 | Overall p<.0001 |
| Non-secretory | 1.2 (.884,1.48), .304 | 1.3 (1.02,1.68), .037 |
| Secretory | 1.3 (1.17,1.45), <.0001 | 1.6 (1.38,1.79), <.0001 |
| Tumor grade (vs. well-differentiated) | Overall p<.0001 | Overall p<.0001 |
| Poor/Undifferentiated | 3.3 (2.88,3.68), <.0001 | 4.5 (3.97,5.03), <.0001 |
| Moderately differentiated | 1.4 (1.21,1.60), <.0001 | 1.4 (1.18,1.58), <.0001 |
| Undetermined | 1.6 (1.49,1.79), <.0001 | 1.9 (1.69,2.03), <.0001 |
| Tumor size ≤39mm (HR multiplies per mm increase) | 1.01 (1.002,1.015), .016 | 1.01 (1.006,1.021), .0007 |
| Tumor >39mm | 1.4 (1.15,1.73), .001 | 1.6 (1.28,1.96), <.0001 |
| T stage (vs. 0/1) | Overall p<.0001 | Overall p<.0001 |
| T2 | 1.0 (.787,1.25), .956 | 1.1 (.806,1.37), .719 |
| T3 | 1.1 (.893,1.41), .322 | 1.3 (1.03,1.71), .031 |
| T4/X | 1.7 (1.34,2.03), <.0001 | 2.1 (1.66,2.64), <.0001 |
| Metastasis | 2.6 (2.41,2.85), <.0001 | 3.2 (2.93,3.48), <.0001 |
a
Model 1= patients 65 and older (pooled adjusted R2=0.33, pooled AUC=0.76)
b
Model 2= patients <65 (pooled adjusted R2=0.30, pooled AUC=0.80)