Fig. 5.

Network analysis indicates that ASCL1 and NEUROD1 have overlapping targets specifically in K27M DIPG. a H3.3 K27M-specific gene regulatory network in DIPG showing enriched motifs in K27M specific ATAC-seq peaks at genes also upregulated in K27M DIPG cells compared to WT DIPG cells. b H3.3 WT-specific gene regulatory network in DIPG showing enriched motifs in WT specific ATAC-seq peaks at genes upregulated in WT DIPG cells compared to their isogenic K27M DIPG counterpart cells