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. 2022 May 20;85(2):174–211. doi: 10.1016/j.jinf.2022.05.016

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© 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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Fig 1 — Antibody titer and T-cell response following the second dose of the BNT162b2 vaccine. (A) Correlation between age and S-IgG levels 1–4 months after the second vaccination dose was measured using Sysmex test. Spearman r, as well as p-values, are presented in each graph. (B) Comparison of antibody levels among different age groups and between the sexes. Data are expressed as box plots: middle line, median; box edges, 25th–75th centile. ***p < 0.001. (C) Kinetics of the antibody titers following the second dose of the vaccine. Correlation between S-IgG levels and the number of days after the second dose. (D) Cellular immunity of participants who failed to develop antibodies against SARS-CoV-2 after the second dose of the vaccine. The number of spot-forming cells per 250,000 in the panel 1 of T-SPOT test was plotted based on the antibody-level groups. The horizontal solid lines indicate the mean of spot-forming cell numbers. The dashed line indicates the threshold of T-SPOT values.