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Adjustment flowchart for the pharmacological treatment of hypertension. ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor-neprilysin inhibitor; BP, blood pressure; CCB, calcium channel blocker; MRA, mineralocorticoid receptor antagonist; RAS, renin angiotensin system; SGLT-2i, sodium glucose cotransporter-2 inhibitor; SPC, single-pill combination.
