Table 1. Association between the IRS and microscopic P. falciparum infection prevalence at the end of the wet and dry seasons.

Survey timing in relation to the IRS and seasonality		Microscopic P. falciparum infection a
		Unadjusted		Adjusted b
		OR (95% CI)	p-value	aOR (95% CI)	p-value
End of wet season (EWS)
	Pre-IRS (Survey 1, October 2012)	1.00	-	1.00	-
	Post-IRS (Survey 3, October 2015)	0.51 (0.45–0.58)	< 0.001	0.47 (0.40–0.54)	< 0.001
End of dry season (EDS)
	Pre-IRS (Survey 2, May/June 2013)	1.00	-	1.00	-
	Post-IRS (Survey 4, May/June 2016)	0.41 (0.35–0.47)	< 0.001	0.36 (0.31–0.43)	< 0.001

For additional information on the adjusted model see S6 and S7 Tables.

OR = odds ratio; aOR = adjusted odds ratio; CI = confidence interval, to deal with the repeated measures the cluster sandwich variance estimator was used

^a Participants were excluded from the model if their antimalarial treatment in the previous two weeks was not known: Survey 3 (N = 79) and Survey 4 (N = 12).

^b Age group, sex, catchment area, LLIN usage the previous night, and anti-malarial treatment in the previous two weeks are adjusted for in the multivariable logistic regression model.