Table 1.
Content and objectives of individual modules
| Module and Dates | Minutes to Complete, Median (IQR) | CME Credit | Overview | Learning Objectives |
|---|---|---|---|---|
|
| ||||
| Series 1 (2017–2018): Genomic medicine in the clinical setting | ||||
| Module 1a,d: What is genomic medicine? Jul-Sept 2017 |
26 (38) | Yes | Foundational material to better understand genomic medicine and how it can impact clinical practice | • Describe genomic medicine. • Interpret a pedigree. • Differentiate between genotype and phenotype. • Determine when to refer a patient for a genetic medicine consult. • Describe PGx and its benefits. |
| Module 2b,d: Current applications of genomic medicine Oct-Dec 2017 |
21 (29) | Yes | Descriptions of genomic applications of precision medicine, including preemptive genomic screening. | • Recognize genomic applications of precision medicine. • Classify the components of genomic medicine. • Describe the Sanford Chip and its clinical utility. • Recognize the strengths and limitations of preemptive precision medicine. |
| Module 3b,e: The genetics of drug response Jan-Mar 2018 |
14 (20) | No | Clinical utility and application of PGx testing and the basics of drug metabolism | • Define PGx metabolizer types in the context of prodrug versus active drugs. • Identify the scientific organizations that create the guidelines for clinical application of PGx. • Recognize the components of the PGx test and utilize decision support tools. • Order PGx testing and apply results. |
| Module 4b,e: Different types of genetic tests and specialists Apr-Jun 2018 |
22 (33) | Yes | Examples of genetic variation and types of tests used to identify each, along with types of genetic specialists available to offer support | • Differentiate between somatic and germline variation. • Summarize the different types of genetic testing. • Recognize the clinical application for each type of genetic testing. • Examine the clinical relevance of the genetic counseling process. • Distinguish the difference between genetic professionals. |
| Series 2 (2018–2019): Clinical applications of genomic medicine | ||||
| Module 5c,f: PGx in patient care Jul-Sept 2018 |
25 (30) | Yes | PGx principles review and common case examples showcasing available clinical decision support tools (recorded video lecture) | • Apply the principles of PGx to patient care. • Recognize cases in which PGx testing is appropriate. • Discuss the advantages and disadvantages of current approaches to PGx testing. • Recognize the components of PGx reports and utilize decision support tools. • Identify clinical resources related to PGx testing. |
| Module 6c,d: The spectrum of genetic variants Oct-Dec 2018 |
16 (16) | Yes | Comparison of the genetics of mendelian and common diseases with an introduction to the identification and analysis of single nucleotide polymorphisms (SNPs) (recorded video lecture) | • Summarize past efforts and current opportunities related to precision medicine. • Outline the spectrum of genetic changes, or variants, between mendelian inheritance and common disease. • Characterize SNPs. • Appreciate the design and clinical utility of genome-wide association studies (GWAS). • Assess the clinical application of polygenic risk scores (PRS) to modify patients’ clinical risk categories for more precise screening and treatment. |
| Module 7b,f: Genetic screening and the Sanford Chip Jan-Mar 2019 |
8 (12) | No | High-level overview of Imagenetics with a focus on the return of results workflow for Sanford’s precision prevention tool, the Sanford Chip | • Describe the three main initiatives of Sanford Imagenetics with an emphasis on the Sanford Chip. • Delineate the Sanford Chip workflow for return of results. • Apply Sanford Chip results to clinical practice through case examples. |
| Module 8b,f: Using genomics to improve management Apr-Jun 2019 |
13 (15) | Yes | Case examples outlining how a genetic diagnosis improves patient outcomes and a brief description of Sanford’s rare disease registry | • Describe how a genetic diagnosis can aid patient care. • Evaluate cases in which referring a patient for a genetic medicine consult may be valuable. • Apply PGx testing results to medical management. • Discuss the value that the Coordination of Rare Diseases at Sanford (CoRDS) provides to patients, families, and researchers. |
a:
Combination of recorded lecture and interactive format
b:
Recorded lecture format
c:
Interactive format
d:
Genetic principles content
e:
Combination of general principles and “how-to” content
f:
“how-to” content