Table 3.
Selected noncoding RNAs involving NLRP3 inflammasome in cerebral I/R injury.
| ncRNA | TUG1 | NEAT1 | MiR-139 | MiR-668 |
|---|---|---|---|---|
| Target | miR-200a-3p | miR-22-3p | c-Jun | Mitochondrial function |
| Expression | Upregulation | Upregulation | Downregulation | Upregulation |
| Species | Adult C57BL/6 mice | Male Sprague–Dawley rats | Human neuroblastoma cells and mouse microglia cells | Male Sprague-Dawley rats |
| Model | MCAO | MCAO | OGD/R | MCAO |
| Treatment | Knockdown of TET2 | Gastrodin | MiR-139 mimics | MiR-668 inhibitor |
| Pathway | TUG1/miR-200a-3p/NLRP3 | NEAT1/miR-22-3p Axis | c-Jun/NLRP3 inflammasome | MiR-668/NLRP3 |
| Therapeutic effect | Attenuate I/R-induced inflammatory response and brain injuries | Improve the neurological scores of rats, reduce the area of cerebral infarction, and inhibit pyroptosis | Inhibit NLRP3 inflammasome-mediated pyroptosis and inflammatory response | Modulate mitochondrial function and regulate NLRP3 signaling |
| Yin et al., 2021 | Zhang et al., 2021 | Wang Q.-S et al., 2020 | He and Zhang, 2020 | |
| References |