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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Proteins. 2021 Feb 15;89(7):781–791. doi: 10.1002/prot.26058

Figure 1.

Figure 1.

Schematic representation of the sequence of (A) hnRNP A1-A with the N-terminal Unwinding Protein-1 domain (UP1) encompassing two RNA Recognition Motifs (RRM1 and RRM2) and the C-terminal Low-Complexity Domain (LCDA1) encompassing the glycine-rich region (Gly-rich), prion-like domain (prLD), M9 nuclear localization signal (M9 NLS), and phosphopeptide (F Peptide). (B) GB1-LCDA1 construct composed of GB1 domain fused with hnRNP A1-A Low-Complexity Domain. This construct encompasses an N-terminal His-tag and a TEV recognition site between the GB1 domain and the LCDA1 domain. (C) Isolated GB1 domain obtained after TEV cleavage of GB1-LCDA1.