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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Proteins. 2021 Feb 15;89(7):781–791. doi: 10.1002/prot.26058

Figure 6.

Figure 6.

Model of the conformational changes experienced by LCDA1 under high-pressure and low temperature conditions. Our data suggest that in standard conditions (atmospheric pressure), LCDA1 adopts a compact conformation stabilized by a mesh-like network of polar and electrostatic interactions (LP state). High-pressure will promote the exposure of polar and charged side chains to solvent, therefore breaking the network of interactions present in the LP state. We hypothesize that the HP state also contains structural motifs that are denaturated at very low temperature.