Fig. 2. Impact of different measures on the incidence of post-transfusion NANBH.

Development of the risk for post-transfusion non-A, non-B hepatitis (NANBH) over time. Over the years, various measures have been taken to reduce the risk of post-transfusion hepatitis. This included the exclusion of paid blood donors, screening for alanine aminotransferase (ALT) levels as well as hepatitis B virus (HBV) infection, and ultimately testing donors for anti-hepatitis C virus (HCV) antibodies and HCV RNA. AIDS, acquired immunodeficiency syndrome; HBsAg, hepatitis B surface antigen. Adapted with permission from ref.²⁶⁵, H. J. Alter.