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There has been a continuous increase in sustained virological response rates over time, starting with only 6–19% when using the first interferon-α (IFN) monotherapies to cure rates of >98% in the era of direct-acting antiviral agents (DAAs)5,65,66,71,73,117,119,146,152,266. HCV, hepatitis C virus; Peg-IFN, pegylated interferon-α; PI, protease inhibitor; RBV, ribavirin.
