Table 1.
Altered abundance of A. muciniphila in various disease states in humans
| Disease | A. muciniphila abundance | Detection method | Sample type | References |
|---|---|---|---|---|
| Allergic asthma | Reduced | qPCR | Faeces | (Demirci et al. 2019) |
| Asthma | Reduced | 16S rRNA sequencing | Faeces | (Michalovich et al. 2019) |
| Alcoholic steatohepatitis (ASH) | Reduced | 16S rRNA sequencing | Faeces | (Grander et al. 2018) |
| Atopy | Reduced | 16S rRNA sequencing | Faeces | (Candela et al. 2012) |
| Atopy | Reduced | Pyrosequencing | Faeces | (Drell et al. 2015) |
| Autism | Elevated | bTEFAP | Faeces | (De Angelis et al. 2013) |
| Autism | Reduced | qPCR | Faeces | (Wang et al. 2011) |
| Clostridium difficile infection | Elevated | qPCR | Faeces | (Vakili et al. 2020) |
| Colorectal cancer | Elevated | 16S rRNA sequencing | Faeces | (Weir et al. 2013) |
| Colorectal cancer | Elevated | qPCR | Tissue biopsy | (Mira-Pascual et al. 2015) |
| Crohn’s disease | Reduced | qPCR | Tissue biopsy | (Png et al. 2010) |
| Crohn’s disease | Reduced | 16S rDNA pyrosequencing | Faeces | (Opstelten et al. 2016; Malham et al. 2019) |
| Cystic fibrosis | Reduced | 16S-based tag-encoded FLX amplicon pyrosequencing (bTEFAP) | Faeces | (Hoffman et al. 2014) |
| Cystic fibrosis | Reduced | Metagenomic sequencing | Faeces | (Hayden et al. 2019) |
| COVID-19 | Elevated | Shotgun sequencing | Faeces | (Yeoh et al. 2021) |
| Oesophageal cancer | Elevated | 16S rRNA sequencing | Tissue biopsy | (Snider et al. 2019) |
| Hyperlipidaemia | Reduced | 16S rRNA sequencing | Faeces | (Gargari et al. 2018) |
| Microscopic colitis | Reduced | 16S rDNA pyrosequencing | Faeces | (Fischer et al. 2015) |
| Multiple system atrophy | Elevated | Metagenomic sequencing | Faeces | (Wan et al. 2019) |
| Obesity | Reduced | qPCR | Faeces | (Marvasti et al. 2020) |
| Obesity | Elevated | qPCR | Faeces | (Remely et al. 2015) |
| Parkinson’s disease | Elevated | qPCR | Faeces | (Unger et al. 2016) |
| Parkinson’s disease | Elevated | Shotgun sequencing | Faeces | (Bedarf et al. 2017) |
| Prediabetes | Reduced | 16S rRNA sequencing | Faeces | (Allin et al. 2018) |
| Psoriasis | Reduced | 16S rDNA pyrosequencing | Faeces | (Tan et al. 2018) |
| Pulmonary arterial hypertension | Reduced | Shotgun sequencing | Faeces | (Kim et al. 2020) |
| Pulmonary tuberculosis | Reduced | Metagenomic sequencing | Faeces | (Hu et al. 2019) |
| Schizophrenia | Elevated | 16S rRNA sequencing | Faeces | (Xu et al. 2020a) |
| Schizophrenia | Elevated | Shotgun sequencing | Faeces | (Zhu et al. 2020) |
| Spleen deficiency syndrome | Reduced | qPCR | Faeces | (Peng et al. 2020) |
| Type 1 diabetes | Reduced | qPCR | Faeces | (Fassatoui et al. 2019) |
| Type 2 diabetes | Elevated | Metagenomic sequencing | Faeces | (Chelakkot et al. 2018) |
| Type 2 diabetes | Elevated | Shotgun sequencing | Faeces | (Qin et al. 2012) |
| Type 2 diabetes | Reduced | 16S rRNA sequencing | Urine | (Liu et al. 2017) |
| Type 2 diabetes | Reduced | Metagenomic sequencing | Faeces | (Zhong et al. 2019) |
| Type 2 diabetes | Reduced | qPCR | Faeces | (Fassatoui et al. 2019) |
| Ulcerative colitis | Reduced | qPCR | Tissue biopsy | (Png et al. 2010) |
| Ulcerative colitis | Reduced | MiSeq sequencing | Faeces | (Bajer et al. 2017) |
| Ulcerative colitis | Reduced | 16S rRNA sequencing | Faeces | (Malham et al. 2019) |