Figure 2.

Analysis of scRNA-seq of tuberculosis lung granulomas

(A) Uniform manifold approximation and projection (UMAP) plot of 109,584 cells from 26 granulomas colored by identities of 13 generic cell types.

(B) Expression levels of cluster-defining genes. Color intensity corresponds to the level of gene expression, whereas the size of dots represents the percent of cells with non-zero expression in each cluster.

(C) Significant correlations between proportion of canonical cell types with bacterial burden of individual granulomas (log₁₀ CFU per granuloma) using non-parametric Spearman’s rho correlation test with Benjamini-Hochberg multiple testing correction. Color indicates binned granuloma bacterial burden.

See also Figures S2, S3, and S5; Table S2.