TABLE 1.

Administration routes of ozone therapy in dermatology

ADMINISTRATION	PREPARATION	METHOD	ADVANTAGES	DISADVANTAGES
Topical	Ozone in water or oil	Immersion or compress	Therapy dosage maintenance/No age restrictions/Low adverse risk	Rapid ozone degradation when in water
Ozone bag	Ozone and oxygen	Topical with containment of gases with appropriate plastic.	Action on bigger lesions	Rapid ozone degradation
Subcutaneous	Ozone and oxygen	Subcutaneous	Local action	No systemic action
Rectal insufflation	Ozone and oxygen	Rectal	Immediate stimulus to cell metabolism	Rapid ozone degradation
Major and minor autohemotherapy	Ozone with individual’s own blood	Intravenous	Immediate stimulus to immune system	Contamination risk