TABLE 3.

Change from baseline of mean FACE-Q scores used in lip filler studies

ARTICLE		Geronemus 2017, Derm Surg19	Rivkin, 2019 Aesth Surg Journal20	Bertucci, 2021 JCD22		Raspaldo, 2015 PRS21; Klassen, 2016 PRS7
PRODUCT		VYC-15L (n=168)	VYC-15L (n=168)	HARK into lips only (n=19)	HARK lips + HARR/HARD mid- face (n=40)	VYC-15L (n=139)	SGP-HA-L (n=142)
TREATMENT SITE		Upper and Lower Lip, Perioral lines OC, PC	Upper and Lower lip, Perioral lines OC, PC	Upper and lowe lip	NLFs and MLs	Upper and Lower Lip, OC, Perioral Lines
INJECTION TECHNIQUE		Tunneling and serial puncture > fanning (for OC)	Tunneling > Serial puncture > Fanning (for OC)	Serial puncture, linear threading, and/or cross hatching		Tunneling > serial puncture and fanning
VOLUME USED (MEAN)		Initial: 2.0 mL, Touch-up: 1.0 mL, Initial + touch up: 2.6 mL	Retreatment: 1.5 mL (median)	1.67 mL (initial + touch up)	Lips: 1.67 mL Midface: 2.65 mL (initial + touch up)	1.97 mL (initial +/- touch up)	1.86 mL (initial +/- touch up)
FOLLOW UP		12 Months s/p last treatment	12 months + 1 month s/p retreatment	8 weeks s/p last treatment	8 weeks s/p last treatment	3 Months s/p last treatment	3 Months s/p last treatment
CHANGE FROM BASELINE OF MEAN FACE-Q SCORE	SATISFACTION WITH LIPS	21.1*	45.5*	33.1*	42.5*	More satisfied compared to Restylane** (scores not reported)	Scores not reported
	APPRAISAL OF LIP LINES	18.8*	38.2*	NR	NR	NR	NR
	SATISFACTION WITH OUTCOME	NR	NR	≥87%	≥87%	More satisfied compared to Restylane** (scores not reported)

*Significant (p<0.05) compared to baseline.

**VYC-15L significantly higher compared to Restylane (FACE Q scores not reported though).

ML: Marionette Line; NLF: Nasolabial fold; NR: not reported; OC: oral commissures; PC: Philtral columns; VYC-15L: Juvéderm Volbella XC® with Lidocaine; SGP-HA-L: small gel particle HA with lidocaine (Restylane-L); HARK: Restylane Kiss; HARR: Restylane Refyne, HARD: Restylane Defyne