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. 2022 May 20;8(20):eabm8786. doi: 10.1126/sciadv.abm8786

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Fig. 1. — Cell lines were established with pTRIPZ-EV, pTRIPZ-HA-NES-GSK3β, and pTRIPZ-HA-NLS-GSK3β in NCI-H1299 cells. Cells were exposed to 1 μM doxycycline for 24 hours. (A) Heatmap of the most significantly altered genes in NCI-H1299 cells expressing EV, NES-GSK3, or NLS-GSK3. (B) GSEA of NES-GSK3– versus NLS-GSK3–expressing cells. NESs and GSEA of ribosome, tRNA biosynthesis, and oxidative phosphorylation are shown. (C) Heatmap of the most significantly altered metabolites from EV-, NES-GSK–, and NLS-GSK3–expressing cells. (D) Heatmap of the expression of genes that mediate serine/one-carbon metabolism in cells expressing EV, NES-GSK3, or NLS-GSK3.