Table 2.

Risk of Bias Assessment of relevant eligible studies.

First author (year)	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel (performance bias)	Blinding of outcome (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other bias	General assessment (low, medium, high)
Ang et al., 2011	L	L	H	H	L	L	Y	High
Blumenstiel et al., 2011	H	H	H	H	L	L	Y	Low
Lambin et al., 2011	H	H	H	H	L	L	Y	Low
Sahin et al., 2011	H	H	H	H	L	L	Y	Low
Burgmer et al., 2012	H	H	H	H	L	L	Y	Low
Craggs et al., 2012	H	H	H	H	L	M	Y	Low
Rhudy et al., 2013	H	H	H	H	L	L	Y	Low
Umeda et al., 2013	H	H	H	H	L	L	Y	Low
Van Oosterwijck et al., 2013	L	L	L	L	L	L	Y	High
Desmeules et al., 2014	H	H	H	H	L	L	Y	Low
Staud et al., 2014	H	H	H	H	L	L	Y	Low
Coppieters et al., 2015	H	H	H	H	L	L	Y	Low
Üçeyler et al., 2015	H	H	H	H	L	L	Y	Low
Bosma et al., 2016	H	H	H	H	L	L	Y	Low
Coppieters et al., 2016	L	L	M	L	L	L	Y	High
Janal et al., 2016	H	H	H	H	L	L	Y	Low
Montoro et al., 2016	H	H	H	H	L	L	Y	Low
De la Coba et al., 2017	H	H	H	H	L	L	Y	Low
Goubert et al., 2017	H	H	H	M	L	L	Y	Medium
Schreiber et al., 2017	H	H	H	L	L	L	Y	Low
De la Coba et al., 2018 b	H	H	M	H	L	L	Y	Medium
De la Coba et al., 2018c	H	H	H	H	L	L	Y	Low
Wodehouse et al., 2018	H	H	H	H	L	L	Y	Low
Brietzke et al., 2019.	H	H	M	L	L	L	Y	Medium
Çelik et al., 2020	H	H	H	H	L	L	Y	Low
Cardinal et al., 2019	H	H	H	H	L	L	Y	Low
De la Coba et al., 2020	H	H	H	H	L	L	Y	Low
Soldatelli et al., 2020	H	H	H	H	L	L	Y	Low
Ydrefors et al., 2020	H	H	H	H	L	L	Y	Low
Al-Mahdawi et al., 2021	H	H	H	H	L	L	Y	Low
Bourke et al., 2021	H	H	H	H	L	L	Y	Low
Donadel et al., 2021	H	H	H	H	L	L	Y	Low
Rehm et al., 2021	H	H	H	H	L	L	Y	Low
Staud et al., 2021	H	H	H	H	L	L	Y	Low

Note. L = Low, M = Medium, H = High, Y = Yes.