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. 2022 May 16;11:e74700. doi: 10.7554/eLife.74700

Figure 5. Model of DNA-PK-mediated DNA end resection in G0 cells.

Figure 5.

Normally in G0 phase at DSBs, the DNA-PK complex promotes DNA end resection. This resection is counteracted by FBXL12. Without DNA-PK, there is no DNA end resection in G0. Without FBXL12, DNA-PK persists at DSBs and leads to more extensive DNA end resection.