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. 2022 May 18;11:e75808. doi: 10.7554/eLife.75808

Figure 1. Structural model of human seipin.

(a) Structure of a seipin subunit. The structure included in the cryoelectron microscopy data is shown in gray. Red loops were modeled with Modeller (Fiser et al., 2000). The blue region was predicted using the yeast structure. The helical structures were extended (yellow). (b) Structure of the human seipin oligomer used in the simulations. Each chain is shown with different colors. (c) Comparison of transmembrane segments of human seipin used in this study (gray) and yeast seipin (blue; PDB 7OXP).

Figure 1.

Figure 1—figure supplement 1. Cryoelectron microscopy of human seipin.

Figure 1—figure supplement 1.

The cyan model includes the seipin luminal domain and partially resolved transmembrane segments. The electron density of Ser165 and Ser166 is shown with yellow. The unidentified density that interacts with Ser165 and Ser166 is shown with red.