Skip to main content
. 2022 May 18;11:e75808. doi: 10.7554/eLife.75808

Figure 4. Cage-like geometry and neck formed by seipin transmembrane (TM) segments are key to modulating the morphology of a forming oil lens.

The first row shows the clipped snapshots of the equilibrated frames, and the second row shows the closeup view of the seipin. The third row shows the nucleation percentage (black) and anisotropy (red). ‘CG simulations of spherical bilayers containing 6% TG with a diameter of 40 nm were carried out’. The elastic network model (ENM) model for seipin with a spring constant of 0.2 kcal/mol/Å2 was used.

Figure 4.

Figure 4—figure supplement 1. The diameter of an oil lens is shown with simulation steps.

Figure 4—figure supplement 1.

Figure 4—figure supplement 2. Coarse-grained (CG) simulation with a spring constant of 2 kcal/mol/Å2.

Figure 4—figure supplement 2.

The bilayer contains 6% triacylglycerol (TG) with a diameter of 40 nm. The clipped snapshot is shown in left, the nucleation percentage (black) and anisotropy (red) are shown in middle, and the diameter of an oil lens (orange) is shown in right.