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Performance of different models when target gene expressions are regulated only by TF expressions, and not by DNA methylation levels. Methods that test pairwise methylation–target associations (corr.met, wilcox.main.met) will identify these DNA methylation–TF–target gene triplets as significant, while methods that consider methylation, TF and target gene simultaneously (lm.binary, lm.cont, rlm.binary, rlm.cont) do not identify these triplets as significant.
