Table 1.
A-to-T mutation signatures for cytosolic and mitochondrial tRNAs in wild type and 5XFAD mice
| tRNA | Mean mutation rate of wild type | Mean mutation rate of 5XFAD | P-value |
|---|---|---|---|
| LysTTT | 45.03 | 35.73 | 0.083789 |
| LeuCAG | 50.35 | 40.94 | 0.09772 |
| GlyGCC | 61.03 | 54.88 | 0.023474 |
| GluCTC | 61.92 | 48.79 | 0.049736 |
| ArgTCT | 64.84 | 63.23 | 0.3794 |
| AsnGTT | 40.95 | 39.95 | 0.502964 |
| ArgCCT | 28.36 | 30.06 | 0.545949 |
| ArgTCG | 19.83 | 17.44 | 0.002312 |
| ValCAC | 63.74 | 46.42 | 0.012823 |
| ThrTGT | 55.96 | 47.81 | 0.019573 |
| ValAAC | 58.99 | 49.04 | 0.018121 |
| IleAAT | 35.77 | 28.82 | 0.174341 |
| SerAGA | 42.18 | 33.91 | 0.221755 |
| TrpCCA | 40.37 | 29.46 | 0.038817 |
| ThrCGT | 12.48 | 11.21 | 0.377434 |
| GlnTTG | 56.98 | 52.15 | 0.020528 |
| ArgCCG | 57.98 | 58.2 | 0.772954 |
| TyrGTA | 28.65 | 17.21 | 0.176075 |
| AlaAGC | 26.4 | 19.86 | 0.28752 |
| LysCTT | 46.83 | 41.47 | 0.00706 |
| iMetCAT | 41.1 | 36.01 | 0.015174 |
| PheGAA | 26.26 | 22.31 | 0.132256 |
| LeuAAG | 20.45 | 18.6 | 0.353735 |
| GlnCTG | 59.29 | 52.73 | 0.05007 |
| LeuCAA | 47.38 | 31.3 | 0.018676 |
| AlaCGC | 43.77 | 32.43 | 0.034584 |
| ArgACG | 38.94 | 22.21 | 0.002146 |
| IleTAT | 37.82 | 29.34 | 0.258774 |
| GlyCCC | 34.62 | 37.31 | 0.74946 |
| CysGCA | 65.17 | 63.75 | 0.857471 |
| chrM:9 | 72.43 | 70.99 | 0.330872 |
| chrM:1033 | 69.41 | 59.12 | 0.016543 |
| chrM:4958 | 64.06 | 53.9 | 0.026689 |
| chrM:6950 | 62.4 | 49.88 | 0.379135 |
| chrM:7708 | 80.75 | 75.64 | 0.48222 |
| chrM:9399 | 75.45 | 64.5 | 0.014056 |
| chrM:9816 | 65.56 | 51.04 | 0.332473 |
| chrM:11553 | 45.86 | 30.19 | 0.025935 |
| chrM:15297 | 39.51 | 34.93 | 0.601065 |