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. 2022 Feb 9;29(5):761–769. doi: 10.1093/jamia/ocac008

Figure 2.

Figure 2.

The effects of dataset harmonization. Overview showing (A) the t-SNE embedding of all 102,880 individuals colored for LISI score prior to harmonization with Harmony and (B) the same post-harmonization, as well as (C) an example showing that relevant structure is maintained by (D) not forcing dataset mixing where local structure is best represented by a small selection of datasets (developmental disorders in children’s hospitals, green arrows in A and B).