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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Neuropharmacology. 2021 Nov 2;202:108860. doi: 10.1016/j.neuropharm.2021.108860

Figure 5. Effect of K4A mutations on U50,488H-induced tolerance in the anti-scratch test.

Figure 5.

WT and K4A mice were treated with saline or U50,488H (80 mg/kg, s.c.) five times in 2 ½ days and tested on the fourth day for anti-scratch effect of U50,488H (5 mg/kg, s.c.) with saline as the control. Data of scratching bouts were normalized to the mean value of each “saline 5x-saline” group and shown as mean ± sem (n= 8-10) and analyzed by one-way ANOVA followed by Tukey’s post-hoc test (Prism 5). $$p<0.01, n.s.not significant, for comparison of “U50 80 mg/kg 5x-U50 5 mg/kg” vs “saline 5x-saline” group; ***p<0.001, **p<0.01, *p<0.05, for comparison of “U50 80 mg/kg 5x-U50 5 mg/kg” vs “saline 5x-U50 5 mg/kg” group; ###p<0.001, #p<0.05, for comparison of “saline 5x-U50 5 mg/kg” vs “saline 5x-saline” group.