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. 2022 May 13;2022:6584645. doi: 10.1155/2022/6584645

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Copyright © 2022 Yeling Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IRAK1 overexpression prominently reversed the influences of AF on viability, inflammation, and cholesterol efflux in Ox-LDL-induced HUVECs. Ox-LDL-treated HUVECs were treated with 100 μM AF or/and IRAK1-overexpressed plasmid, respectively. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 compared with the control group; ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 compared with the Ox-LDL group; ^$P < 0.05, ^$$P < 0.01, and ^$$$P < 0.001 compared with the Ox-LDL+AF-H group. (a) Cell viability was confirmed through CCK-8 in the treated HUVECs. (b) Changes in IL-6 and TNF-α levels were monitored by ELISA kits in each group; ∗P < 0.05 compared with the control group; ^#P < 0.05 compared with the Ox-LDL+AF-H group; ^$P < 0.05 compared with the control group. (c) Cholesterol efflux was certified with the kit in each group.