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. 2022 May 21;111:135–147. doi: 10.1016/j.reprotox.2022.05.012

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Fig. 5 — Impact of remdesivir (RDV) and GS-441524 on the expression levels of the marker genes for the trophectoderm (TE), the epiblast (EPI), and the primitive endoderm (PrE) at E4.5. Embryos are treated from E2.5 to E4.5 with vehicle control (C), RDV at 2 μM (R2), RDV at 4 μM (R4), or GS-441524 at 4 μM (G4). Graphs are qRT-PCR data, showing relative expression levels of each lineage marker, normalized against housekeeping gene Gapdh. Different letters indicate statistically significant differences among treatments (mean ± standard deviation, n = 3 for each treatment group, one-way ANOVA followed by t-test, p < 0.05). No significant difference is observed for Cdx2 and Pou5f1.