Figure 1.

Kaplan–Meier all-cause survival estimates by klotho quartiles. Participants with the lowest serum concentrations of klotho (<666 pg/mL; quartile 1) showed significantly worse survival compared to those with higher klotho concentrations. Time on study treated as the timescale. Log-rank test for differences in the survival curves is 0.006. Mean follow-up: 57.7 months, standard deviation = 28.0.