Table 2.
HRs and 95% CIs for the Association Between Serum Klotho Concentrations and All-cause Mortality (N = 10 069)
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Klotho concentration | ||||||
| >985 pg/mL | 1.00 | Referent | Referent | 1.00 | Referent | Referent |
| 809–985 pg/mL | 1.01 | 0.77, 1.32 | .97 | 1.07 | 0.82, 1.39 | .62 |
| 666–808 pg/mL | 1.04 | 0.73, 1.48 | .81 | 1.06 | 0.77, 1.47 | .72 |
| <666 pg/mL | 1.31 | 1.00, 1.71 | .05 | 1.24 | 0.96, 1.61 | .10 |
| p-trend | .08 | .17 | ||||
| Continuous, per 1-SD decrease (276 pg/mL) | 1.09 | 0.94, 1.25 | .24 | 1.06 | 0.93, 1.20 | 0.36 |
Notes: Model 1 adjusted for age, sex, and survey cycle. Model 2 includes covariates from Model 1 and additional includes for eGFR,body mass index, income/poverty ratio, race/ethnicity, smoking status, physical activity, and educational attainment. CI = confidence interval; HR = hazard ratio.