Table 1.
Patient Characteristics by Histology Group
| Normalized (n = 130) | Quiescent (n = 261) | Active (n = 104) | P | |
|---|---|---|---|---|
| Age at UC diagnosis, median (IQR) | 29.7 (22.6-41.5) | 28.2 (21.0-40.5) | 25.9 (21.2-37.0) | 0.265 |
| Female sex, n (%) | 66 (50.8) | 106 (40.6) | 60 (57.7) | 0.007* |
| Disease duration with UC, median (IQR) | 24.3 (18.4-34.1) | 23.6 (15.9-33.9) | 19.2 (14.3-27.2) | 0.001* |
| Maximum histologic extent, n (%) | 0.001* | |||
| Sigmoid colon | 12 (9.2) | 22 (8.4) | 3 (2.9) | |
| Descending colon | 32 (24.6) | 49 (18.8) | 5 (4.8) | |
| Transverse colon | 6 (4.6) | 20 (7.7) | 9 (8.7) | |
| Ascending colon | 81 (61.5) | 170 (65.1) | 87 (83.7) | |
| Number of colonoscopies per patient, median (IQR) | 6.0 (4.0-9.0) | 5.0 (4.0-8.0) | 4.0 (2.0-5.0) | <0.001* |
| Medication use, n (%) | ||||
| 5-ASAs | 116 (89.2) | 228 (87.4) | 97 (93.3) | 0.262 |
| Immunomodulators | 46 (35.4) | 120 (46.0) | 53 (51.0) | 0.042* |
| Biologics | 29 (22.3) | 76 (29.1) | 40 (38.5) | 0.026* |
| PSC, n (%) | 3 (2.3) | 9 (3.4) | 6 (5.8) | 0.362 |
| Family history of colorectal cancer, n (%) | 20 (15.4) | 29 (11.1) | 18 (17.5) | 0.217 |
| Smoking history, n (%) | 0.053 | |||
| Never | 86 (66.2) | 183 (70.1) | 85 (81.7) | |
| Former | 37 (28.5) | 62 (23.8) | 18 (17.3) | |
| Current | 7 (5.4) | 16 (6.1) | 1 (1.0) | |
| CIB, mean (SD) | 16.5 (9.9) | 20.1 (11.4) | 21.6 (14.5) | 0.002* |
| Documented active histology | ||||
| Before normalization/quiescence, n (%) | 106 (81.5) | 203 (77.7) | — | 0.39 |
| After normalization/quiescence, n (%) | 46 (35.4) | 173 (66.3) | — | <0.001* |
| Documented quiescent histology | ||||
| Before normalization/quiescence, n (%) | 19 (14.6) | — | — | — |
| After normalization/quiescence, n (%) | 31 (23.8) | — | — | — |
Patients categorized according to best histology at any point in their disease course.
*P value denotes statistical significance.
5-ASAs indicate 5-aminosalicylates; IR, interquartile ratio.