Table 3.
HRs of Developing Dysplasia After Patients Achieve Histologic Normalization
| Variable | Univariate Analysis | Multivariate Analysis | P * |
|---|---|---|---|
| Achieved histologic normalization | 0.11 (0.01-0.79) | 0.09 (0.01-0.72) | 0.023‡ |
| Sex | |||
| Male | 3.18 (1.48-6.84) | 2.64 (1.19-5.87) | 0.017‡ |
| PSC | |||
| Yes | 1.82 (0.56-5.94) | — | — |
| Family history of CRC | |||
| Yes | 0.93 (0.36-2.40) | — | — |
| Maximum histologic extent† | |||
| Transverse vs descending | 6.96 (1.27-38.07) | — | — |
| Ascending vs descending | 3.63 (0.87-15.19) | — | — |
| Smoking status | |||
| Former vs no history of smoking | 2.46 (1.26-4.79) | 1.80 (0.89-3.64) | 0.10 |
| Current vs no history of smoking | 0.68 (0.09-5.12) | 0.60 (0.08-4.52) | 0.62 |
| Age at end of follow-up, y | |||
| <50 | Reference | 1.94 (0.77-4.89) | 0.16 |
| 50-75 | 2.14 (0.88-5.21) | 3.29 (0.78-13.92) | 0.11 |
| >75 | 3.26 (0.81-13.10) | ||
| CIB | 0.98 (0.96-1.01) | 0.97 (0.95-1.00) | 0.09 |
*P value for multivariate analysis.
†There were zero patients with maximum histologic extent in the sigmoid who developed dysplasia in this analysis, and therefore these patients were excluded from univariate analysis.
‡ P value denotes statistical significance.